Ceruloplasmin optimal range and reference range

Compiled by Alina Radu, founder of Sera, from the published sources below · Last reviewed November 9, 2026

Sera's bands for Ceruloplasmin, which differ for men and women:

Male: Optimal 19 – 31 mg/dL (0.19 – 0.31 g/L); out of range below 19 or above 31 mg/dL.
Female: Optimal 20 – 51 mg/dL (0.2 – 0.51 g/L); out of range below 20 or above 51 mg/dL.

Evidence grade: Published reference interval. A band that primarily reflects a published adult laboratory or population reference interval. It is not necessarily applicable to every assay or laboratory.

All units

Unit	Applies to	Optimal	Sufficient	Out of range
mg/dL	Male	19 – 31	—	below 19 or above 31
mg/dL	Female	20 – 51	—	below 20 or above 51
g/L	Male	0.19 – 0.31	—	below 0.19 or above 0.31
g/L	Female	0.2 – 0.51	—	below 0.2 or above 0.51

No separate Sufficient band is currently defined for this marker.

What the evidence says

The bands are Mayo Clinic Laboratories' adult intervals: 19 to 31 mg/dL for men and 20 to 51 mg/dL for women (0.19 to 0.31 and 0.20 to 0.51 g/L). Every source, Mayo and four NHS trusts, puts the low edge at about 0.20 g/L, and that is the edge that matters: North Bristol reads below 0.10 g/L as highly suggestive of Wilson disease. Upper edges differ with the assay and with oestrogen (UK laboratories print 0.45 to 0.6 g/L). Ceruloplasmin rises with inflammation, pregnancy and the contraceptive pill, so a high result is common and non-specific. No source supports a narrower optimal range.

Sources

Ceruloplasmin, Serum (CERS) — Mayo Clinic Laboratories (performing laboratory), Duke University Hospital test catalog, 2026 · Laboratory / reference-interval sourceAdult intervals by nephelometry: men 19.0 to 31.0 mg/dL, women 20.0 to 51.0 mg/dL. The basis of Sera's bands.
Caeruloplasmin, serum — Severn Pathology, North Bristol NHS Trust, 2026 · Laboratory / reference-interval source0.20 to 0.32 g/L makes Wilson disease highly unlikely, 0.10 to 0.19 does not exclude it, and below 0.10 is highly suggestive. Supports the 0.20 g/L low edge.
Caeruloplasmin — University Hospitals of North Midlands NHS Trust, Pathology, 2026 · Laboratory / reference-interval sourceUK intervals by sex: women 0.16 to 0.45 g/L, men 0.15 to 0.30 g/L. Confirms the sex split and the male upper edge.
Caeruloplasmin (test directory) — York and Scarborough Teaching Hospitals NHS Foundation Trust, Laboratory Medicine, 2026 · Laboratory / reference-interval source0.2 to 0.6 g/L for all adults, quoted from the Protein Reference Unit. The same 0.2 g/L low edge with a wider upper edge.
216 Caeruloplasmin — University Hospitals Sussex NHS Foundation Trust, Pathology, 2025 · Laboratory / reference-interval sourceAdult interval 0.2 to 0.6 g/L. The same 0.2 g/L low edge.

What Ceruloplasmin measures

The protein that carries most of the copper in the blood, made by the liver.

A low result is the one that matters: it is the first screen for Wilson disease and can also reflect copper deficiency or protein loss. It rises with inflammation, pregnancy and oestrogen, including the contraceptive pill, so a high result is common and rarely specific. Practitioners read it with copper and zinc.

Related vitamins & minerals markers

See Ceruloplasmin in the full list of biomarker ranges

This page is a reference for practitioners, not medical advice. Sera's bands are practitioner targets for structured review, not diagnostic thresholds, and Sera does not diagnose or recommend treatment. Read a result alongside the interval printed by the issuing laboratory and the client's history and symptoms. Range set: Sera Production, version 1.0, last reviewed November 9, 2026.