Myeloperoxidase (MPO) optimal range and reference range

Compiled by Alina Radu, founder of Sera, from the published sources below · Last reviewed November 9, 2026

Sera's bands for Myeloperoxidase (MPO):

  • Optimal 0 – 350 ng/mL (0 – 350 μg/L); sufficient 350 – 500 ng/mL (350 – 500 μg/L); out of range above 500 ng/mL.

Evidence grade: Published reference interval. A band that primarily reflects a published adult laboratory or population reference interval. It is not necessarily applicable to every assay or laboratory.

All units

UnitOptimalSufficientOut of range
ng/mL0 – 350350 – 500above 500
μg/L0 – 350350 – 500above 500
pmol/L0 – 470470 – 540above 540

Bounded on the high side only — a low result is not treated as out of range. The laboratory risk tiers define only a raised result.

What the evidence says

Speaks to plaque vulnerability rather than plaque burden, so it can be raised where the lipid panel looks acceptable. Any neutrophil activation lifts it, so an intercurrent infection makes the result uninterpretable — repeat once well. The ng/mL and pmol/L rows come from different assays and do not convert into one another. The pmol/L bands follow the laboratory risk tiers, ending at 470 and 540. The ng/mL and μg/L bands have no published source mapped to them.

Assay: Results differ meaningfully between platforms and methods. Compare against the interval printed by the issuing laboratory before acting on a borderline value.

Sources

  • Myeloperoxidase (MPO) — reference range — Labcorp, 2026 · Laboratory / reference-interval sourceRisk tiers in pmol/L: low below 470, moderate 470 to 539, high above 539. The edges of Sera's pmol/L bands. The laboratory offers the test for research use, and gives no tiers in ng/mL.

What Myeloperoxidase (MPO) measures

An enzyme released by activated neutrophils within the arterial wall, used as a marker of plaque instability.

Reports on the vulnerability of plaque rather than its extent, which is why it can be raised in someone whose lipids look acceptable. It rises with any neutrophil activation, so an intercurrent infection invalidates the result — repeat it well. The ng/mL and pmol/L scales come from different assays and are not interchangeable.

Related heart health markers

See Myeloperoxidase (MPO) in the full list of biomarker ranges

About the author

Alina Radu is the founder of Sera and a software engineer. The idea started with her own Hashimoto's tests, scattered across years without the big picture. She is not a clinician: these ranges are compiled from the published sources linked on each page, with every source named. Alina Radu on LinkedIn

This page is a reference for practitioners, not medical advice. Sera's bands are practitioner targets for structured review, not diagnostic thresholds, and Sera does not diagnose or recommend treatment. Read a result alongside the interval printed by the issuing laboratory and the client's history and symptoms. Range set: Sera Production, version 1.0, last reviewed November 9, 2026.